April 1958

Addison's Disease in Three Six-Year-Old Boys

Author Affiliations

Nashville, Tenn.
From the Department of Pediatrics, School of Medicine, Vanderbilt University. Present address: Payne Whitney Psychiatric Clinic, 525 E. 68th St., New York (Dr. Malloy); Markle Scholar in Medical Science (Dr. Woodruff).

AMA Am J Dis Child. 1958;95(4):364-369. doi:10.1001/archpedi.1958.02060050366004

Addison's disease is rare in childhood. In reviewing the literature prior to June, 1945, Jaudon1 found 12 cases in children aged 10 years or less. Since that time only 12 cases have been reported in the available literature.2-11 Cases of adrenal failure associated with the adrenogenital syndrome were excluded, as were cases occurring before the age of 2 years, because these appear to be a separate group of patients.12 Among these 12 cases reported, 5 were associated with hypoparathyroidism or moniliasis or had a sibling with this combination of diseases.8-11 Four of these five occurred in two families in which other cases of "the syndrome of familial juvenile hypoadrenocorticism and superficial moniliasis"13 occurred. In none of these cases associated with hypoparathyroidism and/or moniliasis was tuberculous involvement of the adrenal found. Tuberculosis is becoming an unusual cause of Addison's disease in childhood, as it has become in

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