May 1958

Serum Oxaloacetic Transaminase Activity in Acute Rheumatic FeverValues in Cases With and Without Salicylate Therapy

Author Affiliations

Nashville, Tenn.
From the Department of Pediatrics and the Department of Experimental Medicine, Vanderbilt University School of Medicine. Instructor in Medicine (Dr. Massie) and Instructor in Pediatrics and Physiology, Laboratories of Clinical Physiology (Dr. Stahlman), Vanderbilt University Hospital.

AMA Am J Dis Child. 1958;95(5):469-476. doi:10.1001/archpedi.1958.02060050473002

Serum glutamic oxaloacetic transaminase activity is frequently elevated in the presence of acute tissue damage5,6 and has been found to be elevated in acute rheumatic fever.4 Determination of this enzyme might, therefore, be helpful in the diagnosis of acute rheumatic fever and in the evaluation of the presence and severity of rheumatic carditis. In order to define more clearly the value of such determinations, patients with rheumatic fever have been studied during their acute and convalescent periods by relating serum glutamic oxaloacetic transaminase (SGOT) activity to the results of certain other laboratory tests and to the clinical status of the patient. Elevation of serum glutamic oxaloacetic transaminase has also been found during the course of salicylate administration.7 In this study, specific attention has been given to the relationship of salicylate and cortisone therapy to the serological studies and clinical status of the patient.

Methods  Eighteen patients selected

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