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July 1958

Sickle-Cell Anemia in Infancy

Author Affiliations

Washington, D. C.
Mrs. Lily Singer, of the Department of Hematologic Research, The University of Chicago, performed the Tiselius electrophoresis.; From the Department of Pediatrics, D. C. General Hospital, The Research Foundation of the Children's Hospital of the District of Columbia, and The George Washington University School of Medicine.

AMA Am J Dis Child. 1958;96(1):51-57. doi:10.1001/archpedi.1958.02060060053009

Sickling can be produced in the blood of young Negro babies with sickle-cell trait. The percentage of cells showing this change is low but will increase as the infant matures. The homozygous state is present from birth; however, recognition of the symptomatic condition is rare in infants under the age of 4 months. Investigation of the literature reveals only four case reports in infants less than 3 months of age. These cases predate the period when electrophoretic and biochemical procedures could be applied. This article concerns case reports of two infants with sickle-cell anemia who were studied with these methods.

Methods  The erythrocyte and leukocyte counts were made by routine methods. Hemoglobin was determined as cyanmethemoglobin with a Klett-Summerson photoelectric colorimeter.1 The hematocrit values were determined by the Wintrobe method. Tests for sickling were performed by the sealed cover-slip method, with use of sodium metabisulfite as a reducing agent.

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