September 1958

Idiopathic Hypercalcemia of Infancy

Author Affiliations

New Orleans
From the Department of Pediatrics, Ochsner Clinic and Ochsner Foundation Hospital.

AMA Am J Dis Child. 1958;96(3):376-380. doi:10.1001/archpedi.1958.02060060378016

The disease called "idiopathic hypercalcemia of infancy" has received considerable attention in recent European pediatric literature. Butler1 and Fanconi2,3 reported the first two cases in 1951. In 1953 the syndrome was first clearly delineated by Lightwood and Stapleton.4 Since then, many cases have been seen in Great Britain,5-12 where, in fact, the condition appears to be comparatively common. It is reported that in Dundee, Scotland, 5% of all babies entering hospitals between the ages of 6 and 12 months were found to have this disorder.8

By contrast, the disease has been almost unknown in the United States. To date only five cases have been reported in this country.13-15 Doubtless, however, there have been more cases that have been unrecognized, and it behooves the American pediatrician to acquaint himself with the clinical features of the disease. This is especially true because early diagnosis and treatment

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