The present study is concerned with normal values of blood plasma pepsinogen and urine pepsinogen (uropepsin) excretion in infants and children. Recently there has been a revival of interest in this subject, but these investigations have been conducted in the main with normal adults and patients with gastric disturbances and diseases.
Method and Procedure
The study was divided into two parts. One pertained to the determination of blood plasma pepsinogen levels in normal infants and children; the other, to urine pepsinogen (uropepsin) excretion values. Only children free of acute or chronic disease, malignancy, or involvement of the nervous system, as well as allergic, dermatologic, hepatic, metabolic, endocrine, gastrointestinal, cardiopulmonary, hematologic, renal, emotional, or mental disturbance or disease were included in this series. The subjects were obtained at random, as the opportunity presented itself, from private practice, from the outpatient department, or from the inpatient service among those who were admitted
GRAYZEL HG, ELKAN B, SCHNECK L, GARZA SL, CAVILES AP. Plasma and Urine Pepsinogen (Uropepsin) Values in Normal Infants and Children. AMA Am J Dis Child. 1958;96(6):666-675. doi:10.1001/archpedi.1958.02060060668003