December 1958

Plasma and Urine Pepsinogen (Uropepsin) Values in Normal Infants and Children

Author Affiliations

From the Pediatric and Biochemical Departments of the Jewish Hospital of Brooklyn and the Pediatric Department of the State University of New York College of Medicine, Downstate Medical Center. Research Fellows supported by a grant from the Desitin Chemical Company, Providence, R. I. (Mr. Elkan and Drs. Schneck, Garza, and Caviles).

AMA Am J Dis Child. 1958;96(6):666-675. doi:10.1001/archpedi.1958.02060060668003

The present study is concerned with normal values of blood plasma pepsinogen and urine pepsinogen (uropepsin) excretion in infants and children. Recently there has been a revival of interest in this subject, but these investigations have been conducted in the main with normal adults and patients with gastric disturbances and diseases.

Method and Procedure  The study was divided into two parts. One pertained to the determination of blood plasma pepsinogen levels in normal infants and children; the other, to urine pepsinogen (uropepsin) excretion values. Only children free of acute or chronic disease, malignancy, or involvement of the nervous system, as well as allergic, dermatologic, hepatic, metabolic, endocrine, gastrointestinal, cardiopulmonary, hematologic, renal, emotional, or mental disturbance or disease were included in this series. The subjects were obtained at random, as the opportunity presented itself, from private practice, from the outpatient department, or from the inpatient service among those who were admitted

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