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March 1960

Duodenal Polyposis Associated with Mucocutaneous Melanosis (Peutz-Jeghers Syndrome)

Author Affiliations

From the Departments of Radiology and Pathology, University Hospitals of Cleveland, and the Western Reserve University School of Medicine.

AMA Am J Dis Child. 1960;99(3):329-332. doi:10.1001/archpedi.1960.02070030331008

Intestinal polyps are relatively common in children, but those which occur in conjunction with melanotic pigmentation at the mucocutaneous junctions are seen much less frequently. Pediatricians who examine children with intestinal bleeding and find small foci of dark pigment on the lips and adjacent cutaneous and mucosal surfaces should be alert to the possibility of the presence of intestinal polyps as reported by Peutz,5 in 1921, and by Jeghers,4 in 1944.

Report of a Case  A white girl of 10 years was admitted to Babies and Children's Hospital for the investigation of abdominal pain and vomiting. The child had been well until eight months previously, when vomiting first occurred at irregular intervals, averaging perhaps once a week. The episodes took place at different times of day and lasted about half an hour, after which time the patient felt well again. Initially the onset of vomiting was without warning,

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