March 1960

A Study of the Free Amino Acids in Sweat from Patients with Cystic Fibrosis

Author Affiliations

From the Department of Medicine and the Division of Laboratories and Research, Children's Medical Center, and the Department of Pediatrics, Harvard Medical School. Research Fellow (Dr. Ghadimi); Research Assistant (Mr. Stern), and Associate Clinical Professor of Pediatrics (Dr. Shwachman).; 300 Longwood Ave. (15) (Dr. Shwachman).

AMA Am J Dis Child. 1960;99(3):333-337. doi:10.1001/archpedi.1960.02070030335009

There has been a paucity of work on the amino acid composition of sweat in healthy and sick children. In cystic fibrosis of the pancreas the sweat glands excrete sodium and chloride in a concentration far above that found in a control group. The potassium is also elevated but to less extent.1,2 In view of this dysfunction of the sweat glands in cystic fibrosis it appeared reasonable to investigate other components of sweat. Unpublished work from this laboratory indicates that other constituents in sweat from patients with cystic fibrosis, such as urea, lactic acid, citric acid, sulfate, and phosphorus, do not differ from the normal.3 It is intended in this paper to present our findings of the amino acid distribution and of the total α-amino nitrogen concentration in sweat in patients with cystic fibrosis and a control group.

Rothman and Sullivan4 found 11 amino acids in water-wipings

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