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July 1960

Some Observations on Acute Bronchiolitis in Infants

Author Affiliations

Nashville, Tenn.
Department of Pediatrics, Vanderbilt University School of Medicine.; From the Department of Pediatrics, Vanderbilt University School of Medicine.

Am J Dis Child. 1960;100(1):7-15. doi:10.1001/archpedi.1960.04020040009005

Acute bronchiolitis in infants is a respiratory syndrome characterized clinically by generalized emphysema and dyspnea and pathologically by bronchiolitis and interstitial pneumonitis. The etiology is not clear. Trask1 reported 103 children with bronchiolitis which he attributed to Hemophilus influenzae infection. Adams2 states that "the acute bronchiolitis so frequently produced by influenza bacillus is a disease of early life." In other reports, no bacterial species had been found with any regularity. It has been postulated that an unidentified virus probably is involved as the primary etiological agent.3-10 In 1954, Wood, Buddingh, and Abberger11 reported the finding of H. influenzae, Types a and b, from the majority of 51 infants acutely ill with bronchiolitis. Unlike many previous workers, they used cultural methods which favored the growth of these fastidious organisms. Furthermore, it was shown that most of the patients developed agglutinating antibodies against encapsulated H. influenzae during the

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