Years ago I received numerous subcutaneous injections of pollen in the treatment of hay fever. Initially they were given at different sites in my arm. Later I realized that an injection into a small area about two inches above the lateral epicondyle of the humerus was considerably less painful. Since that time, I have had our assistants and the nurses in the hospital use this site for injections and most all report less pain to the patient. Pinch the skin in this area, then pinch the skin on the back of the arm (where most injections are given) and note the difference. And, in this area, there are no important nerves or blood vessels.
If the needle is inserted and the material injected slowly—without jabbing—usually there will be very little pain. Just think of all the injections given to children with so little attention to the relief of discomfort. No
FLEMING TS. Less Painful "Hypos". Am J Dis Child. 1960;100(2):286. doi:10.1001/archpedi.1960.04020040288021