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Article
August 1960

NEW PHENOTHIAZINE ANTIDOTE

Author Affiliations

Columbus Poison Control Center Columbus, Ohio

Am J Dis Child. 1960;100(2):290. doi:10.1001/archpedi.1960.04020040292023

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Abstract

"Extrapyramidal motor reactions" to normal doses of phenothiazine deriva tives are being reported with increasing frequency. Waugh and Metts (New England J. Med. 262:353 [Feb. 18] 1960) point out that, on occasion, these may be life threatening via respiratory embarrassment. A number of oral anti-Parkinsonian preparations as well as intravenous caffeine have been used with varying success in treatment. Many antihistamines are known to have anti-Parkinsonian properties. Consequently, to provide specific therapy rapidly, these authors administered diphenhydramine (Bendryl) 25 mg. intravenously to an affected adult, with prompt relief of symptoms. They recommend that injectable antihistamines be used when such "reactions" occur.

On the basis of our experience at Columbus, where injectable antihistamines in appropriate doses have resulted in prompter alleviation of symptoms than caffeine, we would endorse their recommendations.

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