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December 1960

Attenuated Measles Vaccine (Enders)—The Next Big Advance?

Am J Dis Child. 1960;100(6):807-808. doi:10.1001/archpedi.1960.04020040809001

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Elsewhere in this issue a group of investigators have presented a summary of their studies on attenuated measles vaccine together with their evaluation of the present status of this exciting development in immunization. This short paper, one of eight appearing in a recent issue of The New England Journal of Medicine devoted in its entirety to studies on attenuated measles vaccine, represents the cooperative studies of a number of investigators who have in a unique way combined their efforts to provide a carefully planned evaluation of a live attenuated measles virus vaccine first developed by Dr. John F. Enders and his associates between 1954 and 1958.

In short, this live modified virus vaccine, requiring a single subcutaneous injection of 0.2 ml., results in a 2- to-3-day febrile illness from 7 to 8 days after inoculation. The mean maximum fever is 102.4 F by rectum, but there is apparent well-being in

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