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April 1961

Teratoma of the Thyroid in Newborn Infants

Author Affiliations

University Hospital, University of Maryland, Baltimore, Md.; Departments of Pediatrics and Pathology, University Hospital.

Am J Dis Child. 1961;101(4):505-509. doi:10.1001/archpedi.1961.04020050095014

The term "teratoma" is applied to a group of tumors composed of an admixture of various tissues not normally found at the site where the tumor occurs. Their elements may be derived from 1, 2, or 3 germinal layers, and they may, therefore, be referred to as monodermal, bidermal, or tridermal, respectively. The tissues forming the tumor may have the character of normal tissues, mature or immature, but usually are arranged haphazardly with proportions and architectural relationships unlike the normal. When well differentiated, they are usually benign, with organs or parts of organs recognized histologically. While basically solid tumors, progressive accumulation of secretions of the epithelial components may result in a predominantly cystic tumor. The dermoid cyst is an example of a cystic teratoma in which the tissues are often primarily derived from ectoderm. The teratoma is to be differentiated from hamartoma and mesenchymoma. The hamartoma may contain several tissue

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