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March 1962

Observations on the Seroepidemiology of Measles

Author Affiliations

Dr. Merrill J. Snyder, Section of Infectious Diseases, University of Maryland School of Medicine, Baltimore.; From the Department of Medicine, Division of Infectious Diseases, University of Maryland, School of Medicine.

Am J Dis Child. 1962;103(3):250-251. doi:10.1001/archpedi.1962.02080020262012

Age Distribution of Measles Antibody  A survey of 900 serum specimens from residents of Baltimore, representing all age groups, demonstrated that the acquisition of complement fixing antibodies for measles was most rapid in the second to third and sixth years of life (Figure). Between the 10th and 15th years, the incidence of measles complement fixing antibody reached a maximum of 80% to 90%, which incidence persisted for all ages above 15 years. Geometric mean titers of those positive in each age group were strikingly similar. In all our studies, sex differences were not observed. The age distribution of antibodies was in agreement with previous findings determined by historical methods.1It is to be noted that sera from adults who did not possess complement fixing antibody were invariably positive when tested by tissue culture neutralization. Why in most cases measles complement fixing antibody was retained for life without diminution of

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