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March 1962

Ecology of Measles in Monkeys

Author Affiliations

Harry M. Meyer, Jr., M.D., Division of Biologics Standards, National Institutes of Health, Bethesda 14, Md.; Division of Biologics Standards, National Institutes of Health.

Am J Dis Child. 1962;103(3):307-313. doi:10.1001/archpedi.1962.02080020319025

Some 50 years ago, Goldberger and Anderson 1 demonstrated the susceptibility of macaque monkeys to measles infection. Other workers subsequently confirmed and extended these observations.2,3 Simians played a key role in early studies, since they represented the only known host, other than man, useful as an indicator system for this agent. Investigations were plagued, however, by the unpredictable resistance of some monkeys to the measles virus.4 The explanation for much of this difficulty was furnished by Enders and his associates5 in 1956, when, using modern techniques unavailable to workers of the preceding decades, they showed that 22 of 24 apparently healthy laboratory macaques possessed detectable complement fixing antibodies for measles. In contrast, sera from 21 cynomolgus monkeys bled in the Philippines and an additional 10 newly arrived in Boston from Malaya were devoid of measles antibodies. Ruckle,6 in a separate study during this period, found that

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