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March 1962

Attenuated Measles Vaccine in Cystic Fibrosis

Author Affiliations

Harry Shwachman, M.D., The Children Hospital Medical Center, Boston.; From the Division of Clinical Laboratories and Department of Pediatrics, Harvard Medical School, and the Division of Infectious Disease Research, Children's Hospital Medical Center.

Am J Dis Child. 1962;103(3):405-409. doi:10.1001/archpedi.1962.02080020417048

Cystic fibrosis of the pancreas is a generalized disease of genetic nature chiefly affecting young infants and children. Many mucus secreting glands are involved and characteristically produce a viscid secretion, hence the name mucoviscidosis. In addition, the eccrine sweat glands show a marked functional disturbance with the elaboration of a concentrated electrolyte secretion without affecting the concentration of the other normal constituents of sweat. The name cystic fibrosis, therefore, is a misnomer for this disease because it does not primarily affect the pancreas, nor is it a disease characterized by cyst formation. The survival of patients with this disease depends primarily upon the extent and progression of the pulmonary involvement. In recent years a small number of mild cases have been observed, i.e., children who reach adolescence or young adulthood without having had serious complaints. However, prior to 1948, the outlook for these patients was grave, and the majority of

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