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April 1962

Parent-Child Similarities in Hand-Wrist Ossification

Author Affiliations

Stanley M. Garn, Ph.D., Department of Growth and Genetics, Fels Research Institute, Yellow Springs, Ohio.; From the Department of Growth and Genetics, Fels Research Institute.

Am J Dis Child. 1962;103(4):603-607. doi:10.1001/archpedi.1962.02080020616011

Ever since the advent of radiology, ossification of the hand and wrist has been used as a measure of maturational status. This was true for the original Wilms atlas of skeletal maturation published in 1902,1 and it has remained true for the more recent atlases of Flory,2 Todd,3 and both editions of Greulich and Pyle.4,5

Over the years, however, a few workers have called attention to familial patterns of ossification that complicate the interpretation of hand-wrist radiographs. Pryor, in particular, observed similarities in the ossification sequence of siblings.6,7 Several reports from the Fels Research Institute have stressed family-line similarities in both ossification timing and ossification patterning.8-10 We have previously described a familial syndrome involving the disproportionately late appearance of a cluster of carpal centers11-12 and have demonstrated twin similarities in both the sequences of hand ossification and epiphyseal union.13-14 Recently, we have been able to extend our observations

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