May 1962

Failure to Demonstrate Antiviral Activity of Reticulose

Author Affiliations

C. Henry Kempe, M.D., Department of Pediatrics, University of Colorado Medical Center, 4200 E. 9th Ave., Denver 20.; Department of Pediatrics, University of Colorado Medical Center.

Am J Dis Child. 1962;103(5):655-657. doi:10.1001/archpedi.1962.02080020670004

Introduction  A massive promotional campaign is currently under way in behalf of Reticulose,* a substance claimed to be an antiviral biotic ("The first antiviral biotic with proven clinical results"). The promotional material suggests that indications for the use of Reticulose are "the treatment of viral infections," and over 600 cases are quoted in which the material was said to have been used successfully in a number of virus infections including herpes simplex, infectious hepatitis, encephalitis, generalized vaccinia, mumps meningitis, influenza, infectious mononucleosis, upper respiratory infections, mumps orchitis, and others. It is claimed that Reticulose has demonstrated antiviral properties. A critical review of the bibliography on this material is urged by all readers of this paper.1-5 Therapeutic results claimed in these publications will be analyzed below.The mode of action claimed by the manufacturers and the authors of clinical articles appears obscure. On the one hand immediate relief of symptoms

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