June 1962

Plasma Pepsinogen Levels in the Newborn

Author Affiliations

From Pediatric and Biochemical Departments of the Jewish Hospital of Brooklyn and the Pediatric Department of the State University of New York.; H. G. Grayzel, M.D., Director of Pediatrics, Jewish Chronic Disease Hospital, East 49th St., and Rutland Road, Brooklyn 3.

Am J Dis Child. 1962;103(6):759-764. doi:10.1001/archpedi.1962.02080020776004

Various investigators have indicated that pituitary-adrenal cortical activity affected pepsinogen production and excretion.1-17 Both pregnancy and delivery might be considered as forms of stress, causing stimulation of the adrenal cortex.18,19 Increase in plasma 17-hydroxycorticosteroid levels at the time of delivery18-25 as well as rises in the urinary excretion of glucocorticoids during the last trimester of pregnancy and at the time of parturition have been reported.26,27 17-Hydroxycorticosteroids have been shown to pass through the placental barrier.23,24 Furthermore, in the last trimester of pregnancy, there is an elevation of plasma pepsinogen.28 It was thought, therefore, that it would be of interest to determine the blood plasma pepsinogen levels of normal, full-term infants on the first day of life and during the first week of the neonatal period and compare these levels with those that obtain in older infants and children.

Procedure and Results  Fifty-four infants were

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