August 1962

Male Pseudohermaphroditism and Chromosomal Mosaicism

Author Affiliations

Josef Warkany, M.D., Children's Hospital Research Foundation, Elland Ave. and Bethesda, Cincinnati 29.; Children's Hospital Research Foundation and Department of Pediatrics, University of Cincinnati College of Medicine (Dr. Warkany and Dr. Kauder); Biology Division, Oak Ridge National Laboratory (operated by the Union Carbide Corporation for the United States Atomic Energy Commission), Oak Ridge, Tenn. (Dr. Chu).

Am J Dis Child. 1962;104(2):172-179. doi:10.1001/archpedi.1962.02080030174011

The following is a case report on the subject of chromosomal mosaicism and male pseudohermaphroditism.

Report of a Case  The patient was a Negro boy who weighed 3,020 gm. at birth and appeared entirely normal with the exception of the external ears and genitalia. His mother was 42, the father 47 years old. Consanguinity was denied. The mother had had no miscarriages. Twenty-six weeks prior to delivery she had been admitted to the Cincinnati General Hospital with sudden onset of chest pain. A diagnosis of pulmonary infarct was made, and she was treated with warfarin sodium (Coumadin Sodium) for 2 weeks. She made a satisfactory recovery and remained well thereafter until the time of delivery, when she had mild signs of toxemia. She denied taking drugs except those prescribed in the hospital.The patient had 5 older, normal sibs, their ages ranging from 5 to 23 years. His oldest sister

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