August 1962

Cytomegalic Inclusion Disease in Children with Leukemia or Lymphosarcoma

Author Affiliations

E. C. Beatty, Jr., M.D., 19th Ave. at Downing, Denver 18.; From the Department of Pathology, Children's Hospital.

Am J Dis Child. 1962;104(2):180-184. doi:10.1001/archpedi.1962.02080030182012

Although it is well recognized that the salivary-gland virus is basically a ubiquitous saprophyte that may be demonstrated commonly in human tissues, as well as in tissues in many of the lower animals, without producing disease, it occasionally produces disease in special categories of patients, viz., newborn infants, particularly prematures, as well as in debilitated children and adults.9,10

Cytomegalic inclusion disease (CID) manifests itself in a variety of forms in infants and children.1 In the neonatal period, it may be seen in a premature infant manifesting jaundice, petechiae, and hepatosplenomegaly. The peripheral blood exhibits leukoerythroblastosis. Death usually occurs within 2 weeks as a result of pulmonary, hepatic, or renal insufficiency, or, occasionally, from severe hemorrhage. The postneonatal form may present with diarrhea and vomiting or upper respiratory infection, with death usually occurring within 2 months. Hydrocephalus with necrosis and cortical atrophy of the brain will occasionally have this

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