December 1962

Catecholamines and Diarrhea in Ganglioneuroblastoma

Author Affiliations

Mayo Clinic, Rochester, Minn.; Section of Pediatrics (Dr. Stickler); Section of Surgery (Dr. Hallenbeck); Section of Biochemistry (Dr. Flock and Dr. Rosevear); Mayo Clinic and Mayo Foundation.

Am J Dis Child. 1962;104(6):598-604. doi:10.1001/archpedi.1962.02080030598003

The findings in one patient with a ganglioneuroblastoma who had chronic diarrhea and increased excretion of catecholamines in the urine1 are summarized in a preliminary report. Similar findings had been reported simultaneously by Greenberg and Gardner,2 after several observers3-6 had established that the presence of ganglioneuroma or ganglioneuroblastoma may be associated with chronic diarrhea.

The following 2 cases present evidence that the catecholamines that were measured probably did not cause the diarrhea and that the diarrhea in the one case in which it occurred could be controlled by administration of prednisone.

Report of Cases With Diarrhea  Case 1.—In a 19-month-old boy diarrhea developed which was of such severity that parenteral administration of fluid and electrolytes was required to correct dehydration and to maintain electrolyte balance. Prednisone, given empirically, controlled the diarrhea. After 8 months of therapy, however, signs of hypercortisonism developed, and the child was referred to

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