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The information about chromosomal abnormalities in the human has advanced so rapidly that the average clinician has not been able to keep abreast of it. In order to appreciate fully this new knowledge we must utilize new (to us) words and come to closer grips with the whole field of medical genetics. Since few of us have such a background, this book is extremely worth while. The basic chapters from "DNA, Genes, and Chromosomes" through "Nuclear Sex" are excellent. The introduction, "Chromosomes and the Clinician," is too general in scope. The chapters about chromosomal abnormalities in man are good in terms of documentation but are understandably weak in not having sufficient interpretation or generalization from the data. Under "Sex Chromosome Anomalies in Man" there is too much discussion (for this book) of conditions which do not have a demonstrable chromosomal etiology. As would be expected considering the developments since the
SMITH DW. Chromosomes in Medicine.. Am J Dis Child. 1963;105(1):122. doi:10.1001/archpedi.1963.02080040124026