[Skip to Content]
[Skip to Content Landing]
Article
April 1963

Treatment of Calcinosis Universalis with Chelating Agent

Author Affiliations

DALLAS, TEXAS
Chester W. Fink, M.D., Department of Pediatrics, University of Texas Southwestern Medical School, 5323 Harry Hines Blvd., Dallas 35,; Departments of Pediatrics and Internal Medicine (Rheumatic Diseases Unit), the University of Texas Southwestern Medical School.

Am J Dis Child. 1963;105(4):390-392. doi:10.1001/archpedi.1963.02080040392012
Abstract

Because of the reported favorable effects of chelating agents in calcium deposition diseases,1-5 we are reporting our experience in the treatment of 3 cases of calcinosis universalis presumed secondary to dermatomyositis. The regimen chosen was used by many authors effectively in scleroderma 1-4 and in one reported case of calcinosis universalis.5

Therapeutic Regimen.—Edetate (disodium ethylenediaminetetraacetic acid [EDTA]) supplied as Endrate by Abbott Laboratories was used. Each child received 50 mg. per kilogram in 5% dextrose daily for 5 days. This was followed by a 2-day rest period and the cycle repeated twice for a total of 15 days of therapy. Range of motion at the major joints was measured immediately prior to and immediately after therapy as well as at a subsequent follow-up. No physical therapy was given while the patients were hospitalized, but they were allowed full activity. They were placed on a low-calcium diet during

First Page Preview View Large
First page PDF preview
First page PDF preview
×