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August 1963

Antepartum Survey for Enteropathogenic Escherichia ColiDetection by Cultural and Fluorescent Antibody Methods

Author Affiliations

Dwain Walcher, MD, Professor of Pediatrics, Indiana University Medical Center, 1100 W. Michigan St, Indianapolis 7, Ind.; Research Associate (Janet Nelson); Assistant Professors (Drs. Lewis and Schaffer); and Professor (Dr. Walcher).; From the Department of Pediatrics, Indiana University Medical Center, and the Pediatric Division of Marion County General Hospital.

Am J Dis Child. 1963;106(2):170-173. doi:10.1001/archpedi.1963.02080050172009

Hospital nursery epidemics of diarrhea associated with enteropathogenic Escherichia coli are now well documented. These organisms have been detected in air, dust, and fomites within the hospital environment. Environmental contamination may result from the presence of asymptomatic adult and infant carriers in the absence of overt illness in the nurseries.1 Cooper et al 2 in 1957 reported the presence of enteropathogenic Ecoli in 46 of 361 mothers (12.7%) during their hospital confinement and delivery. Ocklitz and Schmidt 3 in 1957 found enteropathogenic E coli in 5 of 111 mothers attending a prenatal clinic. In one case, the same serotype was isolated from the mother antenatally and the infant after delivery.

The present study was prompted by a recent outbreak of diarrhea in the premature unit of the Marion County General Hospital associated with serotype 0111:B4. The index patient was a premature infant 48 hours of age, with a

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