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October 1963

"Physiologic" Jaundice in Newborn Rhesus Monkey

Author Affiliations

Jerold F. Lucey, MD, Department of Pediatrics, The University of Vermont College of Medicine, Burlington, Vt.; John and Mary Markle Scholar in Medical Science, and Visiting Associate Professor of Pediatrics at the University of Puerto Rico (Dr. Lucey).; University of Vermont College of Medicine, Department of Pediatrics, Burlington, and Laboratory of Perinatal Physiology, National Institute of Neurological Diseases and Blindness, National Institutes of Health, Bethesda, Md and San Juan, and The School of Medicine, University of Puerto Rico, San Juan.

Am J Dis Child. 1963;106(4):350-355. doi:10.1001/archpedi.1963.02080050352002

Introduction  Research into the etiology of human kernicterus has been hampered by the lack of any satisfactory experimental model. A number of animal species, cats, rats, rabbits,1 have been used, but the exact neuropathologic findings of kernicterus have not yet been reproduced experimentally. These animals do not have physiologic jaundice, but they do have deficient hepatic glucuronyl transferase activity in the newborn period.The only known animal species in which kernicterus occurs spontaneously is the Gunn rat,2 but it is not an entirely satisfactory experimental model due to both its small size and to breeding difficulties. The gestational physiology, fetal development, birth, and postnatal growth of the rhesus monkey have been studied enough to know that it is more easily comparable to man than are other laboratory animals.3There have been no previously reported studies on the hematology of the newborn period in the rhesus monkey. Our observations

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