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To the Editor: The causes for growth retardation accompanying nephrogenic diabetes insipidus in children have been related directly to polyuria and polydipsia (Hillman et al: Pediatrics 21:340, 1958); the same relationship has been postulated in patients with diabetes insipidus who respond to exogenous vasopressin (Vest, M. D.; Talbot, N. B.; and Crawford, J. D.: Amer J Dis Child 105:175,1963). Decreased secretion of antidiuretic hormone may characterize some or all of the latter group.
A decreased caloric intake in such patients, noted as long ago as the turn of the century (Weil, A.: Deutsch Arch Klin Med 93:180, 1908), is responsible for the ensuing "hypocaloric dwarfism" (Talbot et al: New Eng J Med 236:783, 1947). A decreased solute intake lessens water intake; the latter is in turn a consequence of the fact that diminished urinary secretion of solutes commands decreased excretion of water. In addition, decreased solute intake may decrease plasma
BERNARDIS LL, TARAIL R. GROWTH RETARDATION ACCOMPANYING DIABETES INSIPIDUS: AN ADDITIONAL MECHANISM?. Am J Dis Child. 1963;106(4):419-420. doi:10.1001/archpedi.1963.02080050421012