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To the Editor: The effect of nutrition on growth is a very significant one although its mechanism remains obscure. In their first account of the amelioration of experimental diabetes insipidus by chlorothiazade administration, Crawford and Kennedy (Nature [London] 183:891, 1959) called attention to the fact that with treatment, animals on constant diet showed an acceleration of weight gain. This effect has been repeadedly confirmed. On a fixed intake, weight gain in animals with experimnetal diabetes insipidus is inversely correlated with water turnover, and the relationship is the same whether reduction of the renal water requirement is due to administration of a thiazide or vasopressin. The relationship obtains as well when reduced water turnover is a function of change to an isocaloric diet presenting a lesser solute residue for excretion in the urine.
The effect of nutrition on skeletal growth of subjects with diabetes insipidus has been investigated both in patients
CRAWFORD JD. GROWTH RETARDATION ACCOMPANYING DIABETES INSIPIDUS: AN ADDITIONAL MECHANISM?. Am J Dis Child. 1963;106(4):420-421. doi:10.1001/archpedi.1963.02080050421013