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Article
December 1963

Immune Globulin Determinations in Allergic Children

Author Affiliations

WINSTON-SALEM, NC
Carolyn C. Huntley, MD, Assistant Professor of Pediatrics, The Bowman Gray School of Medicine, Winston-Salem, NC.

Am J Dis Child. 1963;106(6):545-552. doi:10.1001/archpedi.1963.02080050547003
Abstract

Introduction  Three groups of proteins have been classified as immune globulins. They are:

  1. γ2-globulins, which have a molecular weight of approximately 150,000, a sedimentation constant of 7S, and are known to contain most of the antibodies to viral and bacterial antigens,

  2. γ1A-globulins, known also as B2A-globulins, which have a molecular weight of approximately 150,000 and a sedimentation constant of 7S,

  3. γ1M-globulins, known also as B2M-globulins, which have a molecular weight of approximately 1,000,000, a sedimentation constant of 19S, and are known to contain a number of antibodies including the isohemagglutinins, heterophil antibodies, and typhoid 0 agglutinins.

Serum γ2-globulin concentrations have been previously determined in a group of allergic children by an immunologic method and found to be normal.1 In the present study serum γ1A(B2A)- and γ1M(B2M)-globulin concentrations were measured in allergic children and compared with serum concentrations in normal children and children with nonallergic illnesses.Skin sensitizing

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