August 1964

Auto-Immune Anti-D Specificity in Infancy

Author Affiliations

Samuel Gross, MD, 2103 Adelbert Rd, Cleveland, Ohio 44106.; Assistant Professor of Pediatrics (Dr. Gross) and Assistant Clinical Professor of Pediatrics (Dr. Newman).; Department of Pediatrics, Western Reserve University School of Medicine at Babies and Childrens Hospital.

Am J Dis Child. 1964;108(2):181-183. doi:10.1001/archpedi.1964.02090010183011

In 1953, Weiner et al1 published the first well documented case of a specific auto-immune hemolytic anemia, an adult from whose serum and red cell eluate antibodies with anti-e specificity were isolated. Subsequently, additional reports of specific auto-antibodies appeared in the literature and with rare exception were shown to be part of the Rh system.2-4 Reference to the majority of these cases has been cited by Dacie,5 who noted that the incidence of specific auto-antibodies approximated 30%, with anti-e being the most common. However, prior to 1961, no reports of specificity had been described among the 30 carefully reviewed cases in infants under 1½ years of age.6-8 Shortly thereafter, the first such examples were reported by Laski and co-workers,9 who described a 5½-month-old infant with anti-E and anti-f and a 2½-month-old infant with anti-D antibodies. The present report is a description of anti-D specificity in

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