March 1965

Precocious Menstruation In Hypothyroidism

Author Affiliations

From the Division of Pediatric Endocrinology of the Department of Pediatrics, the Johns Hopkins University School of Medicine and the Children's Medical and Surgical Center of the Johns Hopkins Hospital.

Am J Dis Child. 1965;109(3):252-254. doi:10.1001/archpedi.1965.02090020254010

THE ASSOCIATION of sexual precocity and hypothyroidism was first reported in 1905.1 Since that time ten cases have been documented, most of which have been published within the past five years.2-8

This communication concerns a child who developed hypothyroidism at approximately 9 years of age. Her first menstrual period occurred within 12 months of the onset of symptoms. Periodic menstruation continued until she was again euthyroid after thyroid replacement therapy. Clinical evidence of sexual precocity subsided after the hypothyroidism was adequately treated, there being no recurrence of menstruation over the year since thyroid replacement was begun.

Previously reported cases will be briefly reviewed.

Report of a Case  The patient, a 10½-year-old female, was first seen in the pediatric endocrine clinic at the age of 9 years 10 months for precocious menstruation and rapid weight gain. Her first menstrual period had occurred four months prior to her initial visit.

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