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March 1965


Author Affiliations

Tulane University New Orleans, La 70112

Am J Dis Child. 1965;109(3):261. doi:10.1001/archpedi.1965.02090020263014

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To the Editor: With regard to Dr. Comings' letter ("Re Hyperlysinemia"), the important fact reported about this child is that all observations pointed to a genetic defect that produced impairment of the mechanism for lysine incorporation into protein and indicated that this impairment was at an intracellular level. I encountered enough skepticism of this hypothesis, on the part of knowledgeable people, to make me advance it cautiously. Dr. Comings' acceptance of the idea of impaired protein synthesis and his ingenious selection of a more precisely-defined defect is gratifying.

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