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Article
July 1965

Encephalopathy, Hepatitis and Fat Accumulation in Viscera

Author Affiliations

DANBURY, CONN; ATLANTA; DANBURY, CONN
From the departments of pediatrics and pathology, Danbury Hospital, Danbury, Attending Pediatrician, Danbury Hospital and Clinical Instructor in Pediatrics, Yale University School of Medicine, New Haven, Conn (Dr. Randolph); Resident in Pathology, Danbury Hospital (Dr. Kranwinkel); Public Health Service, Survival and Communicable Disease Center, Atlanta (Dr. Johnson); and Associate Pathologist, Danbury Hospital and Clinical Instructor in Pathology, Yale University School of Medicine (Dr. Gelfman).

Am J Dis Child. 1965;110(1):95-99. doi:10.1001/archpedi.1965.02090030101017
Abstract

Introduction  A PECULIAR, frequently fatal syndrome in children, thought somehow to be related to viral infection, has recently been reported from Australia.1 Characteristically, a mild illness with respiratory and gastrointestinal symptoms of three to five days duration terminates in a 24-hour period of acute cerebral deterioration with disorientation, convulsions, and coma. The major postmortem findings are fatty liver and cerebral edema.An 8-year-old child with such a fatal illness was observed at Danbury Hospital in October 1963. Shortly thereafter, a similar nonfatal illness was observed in a younger sibling. Three other fatalities with similar clinical and autopsy features occurred in a neighboring state within a few weeks of our own case. It is our purpose to alert readers to the possible occurrence of the Reye syndrome in the United States.

Report of a Case  EA, an 8-year-old white boy, was admitted to the Danbury Hospital on Nov 8, 1963

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