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October 1965

Limited Persistence of Virus in Congenital Rubella

Author Affiliations

From the Section on Infectious Diseases, Perinatal Research Branch, National Institute of Neurological Diseases and Blindness, and the Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health.

Am J Dis Child. 1965;110(4):452-454. doi:10.1001/archpedi.1965.02090030472017

RUBELLA virus has been demonstrated to persist in the nasopharynx of children with congenital defects for at least a number of months.1,2 These children also actively produce rubella neutralizing antibody.3,4 The virus has been isolated from many tissues of infants dying with congenital rubella at 1 to 3 months of age.5 Several recent studies have shown that the infected children are also infectious and pose a hazard to personnel working with these patients.6,7 The present study was conducted to determine if virus persists in the nasopharynx of older children and young adults with rubella syndrome defects, and if neutralizing or complement fixing antibody is present in the sera of these patients.

Materials and Methods  Sixteen institutionalized children and young adults were selected for the study. The average age of these patients was 14 years with a range of 5 to 22 years. All of the patients

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