SUBEPENDYMAL cerebral hemorrhage with intraventricular inundation, occurring almost exclusively in premature infants,1-9 has been encountered in approximately 15% of premature babies autopsied in the neonatal period.10 A series of sporadic reports suggested the frequent occurrence of subependymal bleeding in premature infants was due to possible developmental factors such as: (1) thin-walled veins with large diameters that lack adequate supporting fibers in the subependymal matrix,6,11 (2) congenital vascular defects or early vascular injuries,12 or (3) thin-walled terminal veins that are unusually susceptible to venous congestion.6,8,13 The most prevalent theory is that asphyxia produces generalized venous congestion and damage to the cerebral blood vessels which is sufficient to rupture the terminal veins.
The purpose of this report is to present a comprehensive description of the clinicopathological findings of 30 infants who had subependymal bleeding at autopsy and to elucidate further the possible existence of a special predisposition
ROSS JJ, DIMMETTE RM. Subependymal Cerebral Hemorrhage in Infancy. Am J Dis Child. 1965;110(5):531-542. doi:10.1001/archpedi.1965.02090030555007