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Article
May 1966

Studies in Sickle Cell AnemiaXXVI. The Effects of Homozygous Sickle Cell Disease on the Onset of Menarche, Pregnancy, Fertility, Pubescent Changes, and Body Growth in Negro Subjects

Author Affiliations

WASHINGTON, DC
From the departments of pediatrics, medicine, and pathology, Howard University College of Medicine, and the Pediatric Service of Freedmen's Hospital, Washington, DC. Dr. Jimenez is presently at Babies Hospital, Child Development Program, New York City.

Am J Dis Child. 1966;111(5):497-504. doi:10.1001/archpedi.1966.02090080075005
Abstract

EARLIER clinical observations have suggested that patients with sickle cell disease tend to show an increased incidence of complications during labor,1,2 a tendency to lowered fertility,3,4 characteristic hypoplastic genitalia,5,6 eunuchoid habitus,6-11 and are often smaller than their nonanemic siblings.11,12

Studies previously reported by Michelson13 that the average age of menarche in Negroes (with a comparative study by Boas,14 Simmons and Greulich,15 on the age of menarche among white girls), was 12.94±1.1 years in the northern states and 13.68±1.4 years in the southern part of the United States. This variation in the onset in the different regions was believed to be due to a better socioeconomic status of Negroes in the north according to Michelson,13 Engelsman,16 and Gould and Gould.17

During the past three decades, the age of onset of puberty has decreased by ten months in Negroes and

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