OPTIC NEURITIS has been associated with chloramphenicol therapy in both adults and children.1-9 It is our purpose to report two additional cases occurring in children with cystic fibrosis, who were treated with large doses of chloramphenicol over a prolonged period of time.
Report of Cases
Case 1.—This 5-year-old white girl is one of apparently identical twins with moderately advanced cystic fibrosis. The diagnosis was established elsewhere on the basis of symptoms which began at the age of 2 months. The diagnosis was confirmed here at the age of 3 years on the basis of the clinical picture, the chest x-ray, and a sweat test (chloride greater than 100 mEq/liter).Treatment included postural drainage, nighttime mist tent, pancreatic extract, vitamins, and sodium oxacillin at various times. At the age of 4½ years (July 1964), because of progression of her respiratory disease, she was given chloramphenicol in a dose of 750
CHANG N, GILES CL, GREGG RH. Optic Neuritis and Chloramphenicol. Am J Dis Child. 1966;112(1):46-48. doi:10.1001/archpedi.1966.02090100082009