UP TO 1961, only a few cases of malformations in man have been attributed to drugs, notably aminopterin (Thiersch, 1952;1 and 1960;2 Meltzer, 1956;3 and Warkany et al, 19594), busulfan (Diamond et al 19605), androgens and progestogens (Wilkins, 19606), cortisone (Bongiovanni and McPadden, 19607), quinine (Grebe, 1952,8 Uhlig, 1957;9 and Windorfer, 195310), insulin (Wickes, 195411), and tolbutamide (Larsson and Sterky, 196012).
A causal relationship has been well established only for aminopterin and for the androgenic and gestagenic hormones. A few cases of cleft palate following high doses of cortisone administered in early pregnancy are suggestive of a causative effect in view of similar results in animal experiments.
A connection between quinine intake for artificial abortion and malformations has been assumed in selected cases. However, no unbiased study is available. The malformations attributed to quinine have not shown any
LENZ W. Malformations Caused by Drugs in Pregnancy. Am J Dis Child. 1966;112(2):99-106. doi:10.1001/archpedi.1966.02090110043001