September 1966

Mental Retardation With Osteocartilaginous Anomalies

Author Affiliations

From the Sonoma State Hospital, Eldridge, Calif (Drs. Coffin and Siris) and the Department of Medicine, University of California School of Medicine, San Francisco (Dr. Wegienka).

Am J Dis Child. 1966;112(3):205-213. doi:10.1001/archpedi.1966.02090120073006

TWO UNRELATED boys were found to resemble each other in a striking array of anomalies which apparently comprise a syndrome which has not been described before. They are small in stature and retarded in mental development. They have very large, soft hands, pectus carinatum, lax ligaments, anomalies of vertebrae and other bones, and a peculiar facies. The prominent frontal bossing, hypertelorism, downward slant of the eyes toward relatively concave maxillae, prognathism of the mandible, crowded teeth, thick nasal septum, and large, low ears give them a grotesque appearance.

This brief presentation of their histories may lead to the discovery of similar patients in some of the large hospitals and clinics for the retarded.

Report of Cases  Patient A.—At birth the patient weighed 7 lb 4 oz (3,289 gm) and appeared well. The mother was 18 years old. Although there were no complications of pregnancy or delivery the patient was

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