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To the Editor.—The treatment of nocturnal enuresis with imipramine has been reported in the literature since 1960, and the claims to its efficacy vary to extremes. In a large practice of child psychiatry, using the drug in enuretic children ranging in age from 6 to 16 and of middle to lower socioeconomic origin, I have yet to experience a failure with imipramine in over four years of its use. My impression from discussions with other physicians is that failures result more from improper timing of administration than from inefficacy of the imipramine itself. For example, it is of critical importance to determine whether the child is enuretic early or late in his period of slumber, and this information comes only through careful inquiry on the physician's part and persistent parental watchfulness and reporting. "Early" wetters may require the withholding of liquids after supper in addition to the imipramine several
CAHILL CA. IMIPRAMINE IN NOCTURNAL ENURESIS. Am J Dis Child. 1967;114(2):215. doi:10.1001/archpedi.1967.02090230145025