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December 1967

PneumocystosisCurrent Concepts and Recent Advances

Author Affiliations

Merida, Venezuela; Cincinnati
From the departments of Pathology, University de los Andes, Merida, Venezuela, and the Jewish Hospital and University of Cincinnati College of Medicine, Cincinnati.

Am J Dis Child. 1967;114(6):693-699. doi:10.1001/archpedi.1967.02090270149023

PNEUMOCYSTOSIS, NEUMOCYSTOSIS, in epidemic form, has not been observed in the United States with the frequency recorded in Europe. However, isolated cases—especially in connection with underlying lymphomatous diseases and corticosteroid therapy and after the use of radiation or cytotoxic drugs—are more common on this continent than any place else. Pneumocystis carinii has so far, resisted all attempts at culturing, and its exact position in taxonomy is not established. Most observers lean towards a protozoan rather than mycotic position for the agent.

History  Disease in Europe.—Cyst-like organisms were detected in smears of animal lungs by Chagas1 and Carini2 in Brazil more than 50 years ago. Because of the presence of such cysts, the disease is known as pneumocystosis, as well as Pneumocystis carinii pneumonia. Forty years later Vaněk and Jírovec3 and Giese4 recognized similar structures in the alveolar content of the lungs of infants with interstitial

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