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April 1968

Virilizing Tumors of the Adrenal Cortex

Author Affiliations

From the departments of pediatrics, pathology, and surgery, University of Pittsburgh School of Medicine, and the Children's Hospital of Pittsburgh.

Am J Dis Child. 1968;115(4):445-458. doi:10.1001/archpedi.1968.02100010447007

FUNCTIONING neoplasms of the adrenal cortex are clinically manifested by virilization, Cushing's syndrome, feminization, or hyperaldosteronism. In the present report, seven patients with virilizing adrenal tumors are described. In one case, virilization was present from birth. This is a unique instance of in utero virilization attributable to a tumor. Other unusual clinical, pathological, and laboratory findings are being reported.

Methods  The method used for 17-ketosteroid (17-KS) measurements was a modification of that of Callow et al.1 The procedure of Allen et al2 was used for dehydroisoandrosterone (DHA). Pregnanetriol was measured at the BioScience Laboratories, Los Angeles, by Cox's method.3 The 17-hydroxycorticosteroids (17-OHCS) were measured by a modification4 of the method of Glenn and Nelson.5 Aldosterone was estimated in patient 1 by a modification of the procedure of Neher and Wettstein.6 Cathecholamines were measured by the method of Jacobs et al,7 and vanillyl mandelic acid as described