June 1968

Pregnanediol Excretion by Newly Born Infants

Author Affiliations

From the Division of Endocrinology, The Children's Memorial Hospital and the Department of Pediatrics, Northwestern University Medical School, Chicago.

Am J Dis Child. 1968;115(6):693-697. doi:10.1001/archpedi.1968.02100010695008

VERY FEW studies have been reported concerning pregnanediol excretion in the urine of newborn infants.1-5 Roby et al1 measured urinary pregnanediol by a gravimetric method in five normal term infants. Normal values of excretion averaged 250μg on the first day of life fell to 46μg by the sixth day of life. Bergstrand and Gemzell2 measured pregnanediol excretion in children between the ages of 3 and 15 years but have published no information during the neonatal period.2 Utilizing the method of Klopper, an average value of 730 ± 50μg was found in 85 normal children. This finding contrasted with those of Talbot et al3 and Balassi and Ricca,4 who reported that no pregnanediol could be found in the urine of children.3,4 Only one previous report appears in the literature utilizing the method of gas liquid chromatography for analysis of urinary pregnanediol in newborn infants.

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