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Article
June 1968

Wilms' Tumor and Congenital Heart DiseaseReport of a Case and Family

Author Affiliations

Houston
From the Section of Human Genetics, Department of Biology (Dr. Lynch) and the Department of Pathology (Dr. Green), The University of Texas M. D. Anderson Hospital and Tumor Institute, Houston. Dr. Lynch is now with the Creighton University School of Medicine, Omaha.

Am J Dis Child. 1968;115(6):723-727. doi:10.1001/archpedi.1968.02100010725016
Abstract

WILMS' tumor accounts for about 6% of all renal malignant neoplasms. Approximately three fourths of these tumors occur in children under the age of 4 years.1 This neoplasm develops insidiously and may be massive before symptoms are present.

Wilms' tumor is associated with congenital anomalies, of which the most frequently noted is aniridia.2-4 Other associated congenital anomalies include hemihypertrophy, pigmented nevi, hemangiomas, horseshoe kidney, duplication of the upper urinary tract, aplastic or hypoplastic kidneys, cryptorchidism, hypospadias, undescended testes, bilateral small fibrous ovaries, recurved pinna, microcephaly, mental retardation, and multiple neurofibromatosis. Associated cardiac anomalies have included tetralogy of Fallot with patent foramen ovale (one case), aortic stenosis (one case), patent ductus arteriosus (two cases), and patent foramen ovale in two patients at ages 4 and 6 years.5

The present case is of interest from the following standpoints: (1) to document an additional variety of congenital anomalies (transposition of

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