August 1968

Studies of the Inflammatory Cycle in Juvenile Diabetes

Author Affiliations

Columbus, Ohio
From the Children's Hospital Research Foundation and the Department of Pediatrics, Ohio State University College of Medicine, Columbus.

Am J Dis Child. 1968;116(2):130-134. doi:10.1001/archpedi.1968.02100020132003

DIABETIC subjects have frequent associated infections despite adequate humoral antibody production.1 Cellular defense mechanisms have been given little attention in diabetes, though their role in body response to tissue injury by leukocyte emigration is vital. This study of inflammatory response in 35 diabetic children was done to determine if defective leukocyte emigration was present.

Methods  Thirty-five juvenile diabetic patients were studied by Rebuck and Crowley's skin window technique.2 The patients were not acidotic or obviously infected. All had normal peripheral white blood cell counts (WBC) at 5,000 to 10,000/ cu mm. Thirteen normal control children, aged 3 to 20 years, with negative family history for diabetes were also studied. Rebuck and Crowley's skin window technique was used and the inflammatory exudate from a 4-mm sterile abrasion on the volar aspect of the forearm was studied at 2, 5, 8, and 12 hours. The cells responding to the abrasion

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