August 1968

Long-Term Therapy of Chronic Urinary Tract Infection in Children

Author Affiliations

New York
From the departments of medicine (Drs. Kaye and Vianna), urology (Dr. McGovern), and pediatrics (Drs. Shinefield and Rosh), the New York Hospital-Cornell Medical Center, New York. Doctor Kaye is the recipient of a Career Scientist Award of the Health Research Council of the City of New York. Doctor Shinefield is now with the Department of Pediatrics, Kaiser Hospital and University of California Medical Center, San Francisco.

Am J Dis Child. 1968;116(2):166-174. doi:10.1001/archpedi.1968.02100020168008

TREATMENT of patients with chronic urinary tract infection is often unsuccessful.1-3 Urological investigation frequently reveals anatomic abnormalities of the urinary tract which further reduce the chances of successful therapy.1,2

Several investigators4-6 have recommended prolonged antimicrobial therapy for chronic urinary tract infection. However, other studies7,8 have shown no advantage with prolonged therapy. Turck et al9 separated patients in whom treatment was unsuccessful into those who relapsed with bacteriuria due to the same microorganism and those who became reinfected with a different microorganism. These investigators recommended therapy for six weeks or more in those patients who relapsed but felt that prolongation of therapy was of no value in patients who tended to develop reinfection. Still other investigators10 have suggested that prolonged antimicrobial therapy may be of value in patients who tend to become reinfected, and may act as prophylaxis to prevent reinfection.

The present investigation was undertaken to evaluate

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