January 1970

Bone Marrow Metastases in Children With Solid Tumors

Author Affiliations

Los Angeles
From the Division of Hematology and the Department of Pathology, Childrens Hospital of Los Angeles, and the Department of Pediatrics, University of Southern California, Los Angeles.

Am J Dis Child. 1970;119(1):49-52. doi:10.1001/archpedi.1970.02100050051010

Of 213 children with various solid tumors, 493 bone marrow aspirates were examined. Malignant cells were found in bone marrows of 49 of 90 patients with neuroblastoma, 5 of 25 patients with rhabdomyosarcoma, 3 of 13 patients with retinoblastoma, 1 of 13 patients with miscellaneous sarcomas, and 2 of 5 patients with ganglioneuroblastoma. The PAS reaction was helpful in the recognition of rhabdomyosarcoma cells. Tumor cells in the marrows of four of five patients with rhabdomyosarcoma were PAS positive. Bone marrow examinations were useful in selecting an appropriate treatment program, in assessing prognosis, and in determining response to therapy.