February 1970

Hepatic Injury in Chronic Hypervitaminosis A

Author Affiliations

New York
From the Department of Pathology, Mount Sinai School of Medicine and the City University of New York (Dr. Rubin), and the divisions of pediatrics and hematology, North Shore Hospital, Manhasset, NY (Drs. Florman, Degnan, and Diaz). Dr. Florman is now at New York University School of Medicine, New York.

Am J Dis Child. 1970;119(2):132-138. doi:10.1001/archpedi.1970.02100050134008

A 6-year-old girl who suffered from chronic hypervitaminosis A developed hepato-splenomegaly, hepatic dysfunction, and hypersplenism. A liver biopsy specimen displayed large lipid laden Kupffer's cells which were shown to contain vitamin A by fluorescence microscopy. Electron microscopically hepatic injury was indicated by increased lysosomes, focal cytoplasmic degradation, and numerous "light" and "dark" cells. These nonspecific indications of liver cell damage may reflect intracellular release of the biologically active alcohol of vitamin A.