Twelve children with fever and no localized inflammation were found to have occult pneumococcal bacteremia. In all of these children there was a leukocytosis of more than 20,000 white blood cells per cubic millimeter and a predominance of neutrophils and band forms. Five children presented with seizures. Blood culture is recommended for any child with an unexplained fever and convulsion, particularly if leukocytosis is present.
Torphy M, Ray CG. Occult Pneumococcal Bacteremia. Am J Dis Child. 1970;119(4):336-338. doi:10.1001/archpedi.1970.02100050338010