Rectal activity patterns were obtained in 15 children with aganglionic megacolon by open-tipped catheter and were compared with 51 normal children. Bethanechol chloride (Urecholine) was given to six children with aganglionic megacolon and six well children without gastrointestinal complaints, and the responses were evaluated. An increased motor activity during resting periods and a heightened response to cholinergic stimulation with increased wave amplitude were demonstrated in the children with aganglionic megacolon. This evidence supports a concept of spastic contractility in the aganglionic segment of Hirschsprung's disease.
Suster G, Kim IC, Barbero GJ. Rectal Motility Patterns in Infants and Children With Aganglionic Megacolon. Am J Dis Child. 1970;119(6):494-497. doi:10.1001/archpedi.1970.02100050496007