Neurofibromatosis is a relatively common disease characterized by autosomal dominant inheritance, café au lait spots, and neurogenic tumors of the skin and internal organs. The knowledge that neurofibromatosis can involve the intestine and cause chronic blood loss can be important in the diagnosis of obscure chronic anemia. The purpose of this paper is to present a case of chronic anemia secondary to neurofibromatosis.
Report of a Case
A 10-year-old retarded white girl was referred to James Whitcomb Riley Hospital for Children for evaluation of "severe anemia." The patient was admitted to her local hospital in August of 1968 because of lethargy, nervousness, and irritability. A hemogram revealed a hemoglobin level of 4.2 mg/100 cc and a hematocrit reading of 20%; the serum iron value was 22μg/100 cc, and the total iron binding capacity was 390μg/100 cc. A bone marrow aspirate was interpreted as being compatible with iron deficiency anemia. The
Buntin PT, Fitzgerald JF. Gastrointestinal NeurofibromatosisA Rare Cause of Chronic Anemia. Am J Dis Child. 1970;119(6):521–523. doi:10.1001/archpedi.1970.02100050523013